Investigating the adverse effects related with long term use of paracetamol
April 3, 2020
Guidelines often recommend paracetamol as a first-line analgesic, particularly for osteoarthritis (OA), based on its perceived safety. However, there is growing discussion, highlighted in the National Institute for Health and Care Excellence OA (NICE) 2014 guidance on OA, that paracetamol is not as safe as originally thought, especially at the highest therapeutic dose of 4gm/day. …
My Experience as Communication Co-ordinator
March 29, 2020
I was successful in gaining a placement as the Communication Co-ordinator for the NIHR Nottingham Biomedical Research Centre (BRC) MSK Theme, based in the Department of Academic Rheumatology for the spring semester through the School of English placements scheme. Throughout my time here I have been responsible for a number of tasks ranging from involvement …
Effectiveness of inactivated influenza vaccine in autoimmune rheumatic diseases, treated with disease-modifying anti-rheumatic drugs
Researchers at Nottingham University report that seasonal flu vaccine protects from flu and its complications in people with inflammatory conditions treated with immune suppressing medicines. Influenza causes 291,000-650,000 deaths per year globally. Overall, it is estimated to cause 3.1 million hospitalized days and 31.4 million outpatient visits that costs the USA economy 87.1 billion dollars …
Neural adaptations to acute muscle damage in younger and older adults (AMD)
March 10, 2020
Muscle force relies on a combination of altered motor unit (MU) firing rates and recruitment through an increasing range of sizes. However, alterations in these mechanisms may influence muscle functional decline when in a fatigued and damaged state. Although eccentric exercise provokes more significant loss of function, muscle damage and soreness than concentric exercise, it …
Chronic Pain and Work
March 4, 2020
The aim of this study is to develop a toolkit for employees with chronic pain. This toolkit will address the barriers to working for people who experience pain, encouraging self-management through promoting physical and mental wellbeing. It will provide advice on adjustments to work environments in order to create a more inclusive and accessible environment. …
How hand osteoarthritis is associated with hand pain and function
March 2, 2020
Dr Abhishek is currently leading a study that investigates ultrasound markers of symptoms of hand osteoarthritis (OA). OA is the most prevalent form of arthritis, particularly concerning hand joints. The symptoms of OA include; joint swelling, functional impairment, participation restriction and overall reduced quality of life. Despite this, there are no disease-modifying drugs for OA …
The truth behind the pubic rami fracture: identification of pelvic fragility fractures at a university teaching hospital
January 23, 2020
Dawn van Berkel, O Herschkovich, R Taylor, Terence Ong, Opinder Sahota Health Care of the Older Persons, Queens Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, UK Older patients presenting with pelvic fragility fractures(PFF) is an increasing epidemic. The most common pelvic fracture identified by plain radiograph is pubic rami fracture. These fractures are painful …
Investigating Musculoskeletal Health and Wellbeing Newsletter
October 16, 2019
The Investigating Musculoskeletal Health and Wellbeing Newsletter is an annual newsletter keeping you up to date with news from the study and studies linked with it. Here you’ll find some highlights from our community of studies and events.
How lying in bed will help future manned missions to Mars
October 2, 2019
Scientists at the University of Nottingham are helping to push back the boundaries of space travel in a new study to examine a potentially serious adverse effect of weightlessness on the human body. The 3-day bed rest study is being carried out in Nottingham in parallel to a 60-day bed rest study currently …
Muscle mass, metabolic quality and physical function in frail older people with non-weight bearing fractures.
September 5, 2019
“No decline with age is as dramatic or potentially more significant than the decline in lean body mass” (1). In 1989 Rosenberg published this observation and coined the term sarcopenia, a description that has subsequently been extended to incorporate the associated loss of muscle strength and function (2, 3). Muscle loss begins in the fifth …
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