Identifying key elements of non-pharmacological treatment package for fibromyalgia: Evidence synthesis and Delphi exercise

Fibromyalgia (FM) is a long-term condition that causes pain all over the body and currently has no cure. However, there are treatments which can help relieve some of the symptoms and make the condition easier to live with. Burak Kundakci, a PhD student at the University of Nottingham, conducted research into a package of care …

Investigating the adverse effects related with long term use of paracetamol

Guidelines often recommend paracetamol as a first-line analgesic, particularly for osteoarthritis (OA), based on its perceived safety. However, there is growing discussion, highlighted in the National Institute for Health and Care Excellence OA (NICE) 2014 guidance on OA, that paracetamol is not as safe as originally thought, especially at the highest therapeutic dose of 4gm/day. …

Neural adaptations to acute muscle damage in younger and older adults (AMD)

Muscle force relies on a combination of altered motor unit (MU) firing rates and recruitment through an increasing range of sizes. However, alterations in these mechanisms may influence muscle functional decline when in a fatigued and damaged state. Although eccentric exercise provokes more significant loss of function, muscle damage and soreness than concentric exercise, it …