May 15, 2017, by Editor
Pharmacy Research Blog Nov 2016 – Jan 2017
Welcome to our research blog, bringing you highlights from the latest edition of the School of Pharmacy Journal, a quarterly collection of publications and press releases.
The images below represent the design and synthesis of nucleotide monophosphate mimetic eIF4E inhibitors, which are discussed in the following recent publication: Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation published in the European Journal of Medicinal Chemistry.The November 2016 to January 2017 edition of the Pharmacy Journal includes some exciting news from our staff and students including a publication by an MPharm undergraduate!
There was a significant research output in terms of publications and grant capture for the period including about 21 publications, some of which highlight research collaboration between the UK and Malaysia campuses.
In the paper “Cudraflavone C Induces Tumor-Specific Apoptosis in Colorectal Cancer Cells through Inhibition of the Phosphoinositide 3-Kinase (PI3K)-AKT Pathway“, a collaborative effort between researchers at two campuses, they conclude that Cudraflavone C is a PI3K-AKT inhibitor with selective anti-tumor activities against CRC cells.
In another paper “Correlating gastric emptying of amphotericin B and paracetamol solid lipid nanoparticles with changes in particle surface chemistry” collaborators conclude that the rate of the diffusion of simulated media into solid lipid nanoparticles depended on the solubility of the loaded-drug in the particular medium.
On 18 January, Dr. Daniel G. Anderson, Massachusetts Institute of Technology, Koch Institute, gave a lecture to about 300 staff and students from across the University. This exciting talk ‘Nucleic acid delivery systems for RNA therapy and gene editing’ was part of the launch of the Inaugural Biomaterials Discovery Workshop which will be held annually at the University, associated with our £6.5M EPSRC Programme Grant in Next Generation Biomaterials.
Professor Phil Williams
Director of Research and Knowledge Exchange
Professor Nashiru Billa
Associate Dean (Research)