![Fig. 1. (a) mRNA cap recognition (represented by m7GTP shown as yellow CPK sticks) and binding of eIF4G or 4E-BPs (represented by a peptide derived from 4E-BP1 shown as a cyan cartoon) occurs on opposite faces of eIF4E (green cartoon). Apart from direct cap-binding antagonists, allosteric inhibitors (binding pose of 4-EGI1 [22] shown as magenta sticks) and inhibitors derived from eIF4G and 4E-BPs [23] are being developed. Whereas m7GTP-binding is dominated by polar interactions between the cationic N-methylpurine system and eIF4E residues W56, W102, and E103 (cationep interaction and H-bonds), as well as the phosphate groups with residues R157, K159, and K162,](https://blogs.nottingham.ac.uk/pharmacy/files/2017/05/Journal-sq-418x300.jpg)
Pharmacy Research Blog Nov 2016 – Jan 2017
May 15, 2017
Welcome to our research blog, bringing you highlights from the latest edition of the School of Pharmacy Journal, a quarterly collection of publications and press releases. The images below represent the design and synthesis of nucleotide monophosphate mimetic eIF4E inhibitors, which are discussed in the following recent publication: Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation …
School of Pharmacy Research Blog – October 2014
October 23, 2014
Dear All Welcome to the pharmacy school research blog which covers updates from our research activity including all the developments on big advances in research and publications, press releases in the pharmaceutical sciences Nottingham is the Top School of Pharmacy in England The 2015 Guardian University Guide and 2015 Complete University Guide have been published …
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