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Genetics and genomics – when metaphors begin to matter

I remember in the not so distant past standing in the Wellcome Sanger Institute in Cambridge admiring the huge sequencing machines and chatting about public engagement with colleagues before giving a talk about genomics and metaphors. I also remember writing some things about gene editing and metaphor. In my mind all this related to basic …

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Astrogenomics: Integration and inspiration

I should have blogged about embryo editing in Russia. I should have blogged about Netflix’s ‘Unnatural selection’ series on CRISPR and genome editing. I should have blogged about prime editing, but life is getting in the way at the moment. That doesn’t mean I don’t look at twitter once in a while (au contraire!). So, …

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Participation at the core: AI, ELSI and community engagement

Alondra Nelson, a sociologist, STS scholar and expert on AI policy and ethics, recently published a letter in Science proposing that artificial intelligence (AI) should adopt the Ethical, Legal, and Social Implications (ELSI) framework from genomics, an approach designed to put social concerns at the heart of technology governance. Nelson argues that meaningful community engagement …

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Synthesising genomes: Future promises, past metaphors

Yesterday morning I was packing for a holiday and briefly listened to the Today programme on Radio 4, just at the time that Pallab Ghosh was talking about a new initiative funded by the Wellcome Trust, namely a new Synthetic Human Genome (SynHG) project. I didn’t really have time to listen or read about it …

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The (not) de-extinct dire wolf: Metaphors, myths and magic

This post is a collaboration between Brigitte Nerlich and Kate Roach, both retired social scientists with interests in science, culture and society. *** I (Brigitte) first heard about the dire wolf in a post by the science writer Carl Zimmer linking to an article he had written for the New York Times. I had never …

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When the world falls apart, enjoy a metaphor!

I have been writing blog posts since 2012. They dealt mainly with topics relating to climate change, the biosciences, infectious diseases, and more recently AI. Occasionally, I branched out into space or into the 19th century. That happened at times when the tectonic plates of politics shifted, such as after Brexit, the first Trump government, …

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Making Science Public 2024: End of year round-up of blog posts

It’s that time of year again when I write my round-up of all the blog posts that I have written over the year. There were more posts than I expected. I have tried to group them into topics, some of which you might be interested in, others not. This year, I mostly explored the ever-expanding …

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From large language models to DNA language models

In October 2023 I wrote a blog post about a convergence of large language models or LLMs and DNA. LLMs are subset of generative AI that focus on generating and understanding human language and producing human-like text. DNA is often compared to a language or a code. In the post I quoted a representative of …

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The genome as autoencoder: A new biological metaphor

I am just back from a walk thinking about Kevin Mitchell and Nick Cheney’s recent paper (preprint) on the genome as autoencoder, rather than a blueprint or recipe. This paper caused quite a stir and you can find a good summary in this post by Jessica Hamzelou for the MIT Technology Review. Walking along, I …

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Blueprints, postmen and a bit of metaphor archaeology

At the end of June, the NHS announced a new gene therapy for haemophilia B. Gene therapy replaces a faulty gene or adds a new gene to correct a mutation (genetic fault). People with haemophilia B lack the blood clotting protein factor IX and can bleed severely from even a slight injury. Some therefore need frequent …

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