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Genome editing: Invisible mending

Last week I had a few days in Oxford to visit old haunts, such as the Ashmolean, the Museum of Natural History and the Pitt Rivers Museum. I also went to a little exhibition in the basement of the Museum of the History of Science. The exhibition by Anna Dumitriu was entitled BioArt and Bacteria. …

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Genome editing, metaphors and language choices

Genetic Alliance and the Progress Educational Trust recently published a report entitled ‘’Basic understanding of genome editing”, based on research supported by the Wellcome Trust. As I have worked on metaphors relating to genetic, genomics and genome editing for more than twenty years, I was particularly interested in this report. Unlike many other publications, including …

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Base editing, biological complexity and the limits of metaphorical explanation

Gene editing has been in the news since around 2013. Here I want to focus on one of the most recent advances which made me question my own understanding of gene editing. In 2015 a team of scientists led by Junjiu Huang at Sun Yet-Sen University in Guangzhou, China, used gene editing techniques, in this …

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Gene surgery – Genchirurgie

On 22nd October 2016 Roland Jackson tweeted that he was going to Berlin to participate in a trilateral meeting of English (Nuffield Foundation on Bioethics), German and French bioethics committees on gene/genome editing. I tweeted back and asked whether there would be a report; he tweeted an older press release by the German Ethics Council …

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CRISPR and genome editing: Real and imagined

For several years now there has been a buzz around a new advance in genomics called genome (or gene) editing. “Genome editing is the deliberate alteration of a selected DNA sequence in a living cell.” Scientists have been able to do gene editing for a while, but to find and replace any sequence in any …

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On the metaphorical origins of gene drives

This morning I woke up to a bit of chat about ‘gene drive‘ – this year’s science breakthrough of the year –, first on twitter, then on the radio. This made me think about the use of terms like gene drive, gene driver, gene driving and where they come from. It also made me think …

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The book of life: Reading, writing and editing

I have been observing the use of the ‘book of life’ metaphor in genetics and genomics since the year 2000, when it was used to announce that the human genome, our entire DNA, had been roughly sequenced. The Human Genome Project had begun in 1990 and was completed in 2003. Its achievement consisted in finding …

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Making epigenetics public: A problem with metaphors

This article has been co-authored with Aleksandra Stelmach Two years ago, in May 2013, I wrote a blog post about epigenetics. This was at a time when social scientists started to be interested in this new field of genetics/genomics and began to critically scrutinize it. Now, two years later and after a flurry of social …

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From recombinant DNA to genome editing: A history of responsible innovation?

In this post I shall report on a recent call for ethical and regulatory reflection by scientists engaged in a new genomic technology. I’ll then put this into a historical context of previous initiatives of that kind, and finally ask whether this can be called ‘Responsible Research and Innovation’. CRISPR Recently, a new controversy has …

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Sickle cell disease and identity

In my background post, I tried to provide some information about what sickle cell disease is, how it has so far been treated and what a new therapy using gene editing might involve. When such as treatment possibility was announced as approved by health agencies in the UK and the US, newspapers took (some) notice, …

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