Search for "genomics"

Genetics and genomics – when metaphors begin to matter

I remember in the not so distant past standing in the Wellcome Sanger Institute in Cambridge admiring the huge sequencing machines and chatting about public engagement with colleagues before giving a talk about genomics and metaphors. I also remember writing some things about gene editing and metaphor. In my mind all this related to basic …

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Astrogenomics: Integration and inspiration

I should have blogged about embryo editing in Russia. I should have blogged about Netflix’s ‘Unnatural selection’ series on CRISPR and genome editing. I should have blogged about prime editing, but life is getting in the way at the moment. That doesn’t mean I don’t look at twitter once in a while (au contraire!). So, …

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From large language models to DNA language models

In October 2023 I wrote a blog post about a convergence of large language models or LLMs and DNA. LLMs are subset of generative AI that focus on generating and understanding human language and producing human-like text. DNA is often compared to a language or a code. In the post I quoted a representative of …

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Using Claude for science communication: The case of the genome as autoencoder

I am just back from a walk thinking about Kevin Mitchell and Nick Cheney’s recent paper (preprint) on the genome as autoencoder, rather than a blueprint or recipe. This paper caused quite a stir and you can find a good summary in this post by Jessica Hamzelou for the MIT Technology Review. Walking along, I …

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Blueprints, postmen and a bit of metaphor archaeology

At the end of June, the NHS announced a new gene therapy for haemophilia B. Gene therapy replaces a faulty gene or adds a new gene to correct a mutation (genetic fault). People with haemophilia B lack the blood clotting protein factor IX and can bleed severely from even a slight injury. Some therefore need frequent …

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Hunting for AI metaphors

Thousands of articles and blog posts have been written about generative AI, especially ChatGPT. Some or these, especially blog posts, are about metaphors. As a metaphor hunter (see image!) I feel a bit ashamed that I haven’t done much on metaphor and AI. A little bit yes; for example, on what metaphors ChatGPT uses about …

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Vaccine hesitancy in Europe: A conceptual exploration

Many things changed rather fast when the Covid-19 pandemic spread around the world at the beginning of 2020. There were new social phenomena, like ‘social distancing’, a so-called non-pharmaceutical intervention intended to stop the spread of the coronavirus. There were new scientific and bodily phenomena, like quickly developed vaccines, so-called pharmaceutical interventions intended to stop …

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Genes, trains and eureka-moments

I was in the process of writing a blog post on metaphors in genetics and genomics which was getting longer and longer and I had some personal stuff to deal with. So, I stopped. I might come back to this another time. In the process of writing, I discovered that trains have been quite an …

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Making science public 2023: End-of-year round up of blog posts

The year 2023 began with a bang. Suddenly there was a new form of ‘artificial intelligence’, and by ‘new’ I mean a form of AI that even I could use and vaguely understand. There was, it seems, some monstrous machine (called LLM) gobbling up everything we have ever produced in science, literature and art and …

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What are metaphors (for)?

I have been thinking about metaphor for a long time. But I have never brought my core thoughts together in one place. Here we go… and of, of course, they are not just my thoughts…they are inspired by a myriad of thinkers from the 19th century onwards, including, of course, George Lakoff and all those …

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